Relationrx
Director, Clinical Pharmacology
Salary not disclosedHybrid
- Drug Discovery
- London
- Full time
- Today
About the role
The Director of Clinical Pharmacology will lead the clinical pharmacology and pharmacometric capability to support the company's drug discovery and development portfolio. This role involves driving end-to-end asset development, applying Model-Informed Drug Development (MIDD) approaches, and integrating non-clinical and clinical data to optimize dosing strategies and trial designs. You will serve as the core quantitative lead within cross-functional project teams, working across various therapeutic modalities to translate data into actionable insights.
Responsibilities
- Build and own the clinical pharmacology and pharmacometric capability to support product development goals.
- Act as the Clinical Pharmacology lead for multiple concurrent programmes across indications and therapeutic modalities.
- Oversee clinical pharmacology input into study design across the full range of development.
- Lead modelling and simulation approaches, including PBPK, population PK/PD, and QSP to characterise developability and exposure-response relationships.
- Lead and manage external collaborations and CRO partnerships to ensure effective execution and delivery.
- Author relevant sections of regulatory documents, including Investigator's Brochures, INDs, and NDA/BLA/MAA submissions.
- Proactively identify and incorporate emerging AI-enabled approaches into clinical pharmacology workflows.
Required skills
- Clinical Pharmacology
- Pharmacometrics
- Model-Informed Drug Development
- MIDD
- PK/PD
- NONMEM
- R
- Monolix
- WinNonlin
- GastroPlus
- SimCyp
- Drug Discovery
Nice to have
- Small molecules
- Biologics
- AI-enabled approaches
Qualifications
- PhD, PharmD, or MD with a specialisation in DMPK, Pharmacometrics, in vivo/Clinical Pharmacology, or a related scientific discipline
- Equivalent industry experience in a lead Quantitative Clinical Pharmacology position
About the Company
Relation is a TechBio company that leverages single-cell multi-omics, functional assays, and machine learning to understand human biology and discover therapies for devastating diseases. The company operates in a highly interdisciplinary environment with state-of-the-art wet and dry labs based in London.